Fractionated dose of 60 Gy changes molecular response of HL-60 cells to irradiation
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چکیده
منابع مشابه
Dose- and Time-Dependent Response of Human Leukemia (HL-60) Cells to Arsenic Trioxide Treatment
The treatment of acute promyelocytic leukemia (APL) has been based on the administration of all-trans retinoic acid plus anthracycline chemotherapy, which is very effective as first line therapy; however 25 to 30% of patients will relapse with their disease becoming refractory to conventional therapy. Recently, studies have shown arsenic trioxide to be effective in the treatment of acute promye...
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Background: Neutrophils are the most abundant white blood cells in humans. Recently, a novel strategy called the formation neutrophil extracellular traps (NETs) was described. NETs is a new strategy for pathogen response. This study focused on whether LPS induced NETs release in vitro in the HL60 cell line. Methods: In this study, the HL60 cell line was used for culture and DMSO for induction ...
متن کاملChanges in susceptibility to Fas-mediated apoptosis during differentiation of HL-60 cells.
The Fas-mediated pathway has been implicated as an important cellular pathway mediating apoptosis in diverse cell types. We conducted studies to examine the susceptibility to Fas-mediated apoptosis of HL-60 cells treated with differentiation-inducing factors such as dimethyl sulfoxide (DMSO), retinoic acid (RA), and 1alpha, 25 dihydroxyvitamin D3 (VD3). Although the expression of Fas antigen (A...
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Myeloperoxidase (MPO) is a cationic protein and one of the major constituents of azurophilic granules in neutrophils. Here, we examined whether intracellular transport of MPO and serglycin, a chondroitin sulfate (CS)-bearing proteoglycan, is correlated. First, we examined binding of MPO to CS-Sepharose and measured an ionic interaction, which was disrupted by 200-400 mM NaCl. Next, HL-60 promye...
متن کاملNoteApoptosis to HL-60 by Humuione
We found und isolated a strong bonc resorption inhibitor, hurnulone (HU), fi'om hop extract recently.i] 'E'o study the mechanism of the inhibition of bone resorpt{on, we have choscn the preTnyclocytic lcukemia ccli HL-60. Although the target cetl for the humulone molecuge is not clear, one of the candidates for the target cell is osteoclasts. 1'he celE line of osteoclasts has not been establish...
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ژورنال
عنوان ژورنال: Radioprotection
سال: 2008
ISSN: 0033-8451,1769-700X
DOI: 10.1051/radiopro:2008649